{"id":3826,"date":"2019-12-17T18:42:23","date_gmt":"2019-12-17T10:42:23","guid":{"rendered":"http:\/\/woodrefinery.com\/zhenfang\/?p=3826"},"modified":"2020-09-12T17:36:20","modified_gmt":"2020-09-12T09:36:20","slug":"cycloamination-strategies-for-renewable-n-heterocycles","status":"publish","type":"post","link":"https:\/\/woodrefinery.com\/zhenfang\/cycloamination-strategies-for-renewable-n-heterocycles\/","title":{"rendered":"Cycloamination strategies for renewable N-heterocycles"},"content":{"rendered":"

Cycloamination strategies for renewable N-<\/em>heterocycles<\/strong><\/p>\n

Recently, Dr. H Li and Prof. Zhen Fang, collaborated with Prof. RL Smith Jr. (Tohoku University, Japan), published a review (Spotlight) paper in Green Chemistry about the production of renewable N-heterocycles.<\/p>\n

Biomass resources have infinite possibilities for introducing nitrogen, sulfur, or phosphorus heteroatoms into their structures by virtue of controllable carbon-heteroatom bond formation. In this review, cycloamination approaches for thermal (catalyst-free) and catalytic transformation of biomass feedstocks into N-heterocyclic molecules including mechanistic pathways are analyzed. Bottom-up (small molecule substrates) and top-down (large molecule substrates) are considered. Sustainable routes for synthesis of five-membered (pyrroles, pyrrolidones, pyrazoles, imidazoles), six-membered (pyridines, pyrazines), fused (indoles, benzimidazoles), and other relevant azaheterocycles are critically assessed. Production of biomass-derived six-, seven-, and eight-membered as well as fused N-heterocyclic compounds with present approaches have relatively low selectivities. Attention to methods for forming analogous sulfur or phosphorus heteroatom compounds from biomass resources using either bottom-up or top-down strategies appear to have been greatly overlooked. Synthetic auxiliaries (heating modes, nitrogen sources) that enhance reaction efficiency and tunability of N-heterocyclic ring size\/type are considered and plausible reaction mechanisms for pivotal pathways are developed.<\/p>\n

\"\"<\/p>\n

Efficient amination strategies for synthesis of N-heterocycles from functional molecules (bottom-up) or from biomass (top-down) via sustainable C-N\/C-X bond chemistry \uff08\u4ece\u529f\u80fd\u5206\u5b50(\u81ea\u4e0b\u800c\u4e0a)\u6216\u4ece\u751f\u7269\u8d28(\u81ea\u4e0a\u800c\u4e0b)\u901a\u8fc7\u53ef\u6301\u7eed\u78b3- n \/C-X\u952e\u5316\u5b66\u5408\u6210n\u6742\u73af\u7684\u9ad8\u6548\u80fa\u5316\u7b56\u7565\uff09<\/p>\n

Related results were accepted in Green Chemistry:<\/p>\n

H Li*, HX Guo, Zhen Fang*, TM Aida, RL Smith Jr*, Cycloamination Strategies for Renewable N-heterocycles, Green Chemistry,\u00a0https:\/\/doi.org\/10.1039\/C9GC03655E\u00a0<\/a>, 22<\/strong>, 582-611, 2020<\/strong> (Spotlight Paper, Review).<\/p>\n

————————————<\/p>\n

\u674e\u864e\u535a\u58eb\u5728\u56fd\u9645\u5b66\u672f\u671f\u520a<\/strong>Green Chemistry<\/strong>\u53d1\u8868\u5b66\u672f\u8bba\u6587<\/strong><\/p>\n

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\u8be6\u60c5\u53ef\u89c1\uff1a<\/p>\n

H Li*, HX Guo, Zhen Fang*, TM Aida, RL Smith Jr*, Cycloamination Strategies for Renewable N-heterocycles, Green Chemistry (IF 9.4),\u00a0https:\/\/doi.org\/10.1039\/C9GC03655E<\/a> 22<\/strong>, 582-611, 2020<\/strong> (Spotlight Paper, Review).<\/p>\n","protected":false},"excerpt":{"rendered":"

Cycloamination strategies for renewable N-heterocycles […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/woodrefinery.com\/zhenfang\/wp-json\/wp\/v2\/posts\/3826"}],"collection":[{"href":"https:\/\/woodrefinery.com\/zhenfang\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/woodrefinery.com\/zhenfang\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/woodrefinery.com\/zhenfang\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/woodrefinery.com\/zhenfang\/wp-json\/wp\/v2\/comments?post=3826"}],"version-history":[{"count":5,"href":"https:\/\/woodrefinery.com\/zhenfang\/wp-json\/wp\/v2\/posts\/3826\/revisions"}],"predecessor-version":[{"id":4066,"href":"https:\/\/woodrefinery.com\/zhenfang\/wp-json\/wp\/v2\/posts\/3826\/revisions\/4066"}],"wp:attachment":[{"href":"https:\/\/woodrefinery.com\/zhenfang\/wp-json\/wp\/v2\/media?parent=3826"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/woodrefinery.com\/zhenfang\/wp-json\/wp\/v2\/categories?post=3826"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/woodrefinery.com\/zhenfang\/wp-json\/wp\/v2\/tags?post=3826"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}